The hottest new betting market is mice motor skills

DeSci platform pump.science announced a partnership with Solana-based prediction market Hedgehog Markets

article-image

Helen Hotson/Shutterstock modified by Blockworks

share


This is a segment from the Lightspeed newsletter. To read full editions, subscribe.


Market watchers have cast doubt on prediction markets’ ability to draw meaningful volumes after the presidential election. Enter: Livestreams of drugged-up mice trying to balance on a rotating rod. 

The so-called DeSci platform pump.science announced a partnership with Solana-based prediction market Hedgehog Markets whereby users can place bets on the outcomes of longevity experiments on mice. It’s arguably a move in a more reputable direction for the speculative DeSci trend, which has drawn criticism for creating misaligned incentives. 

Decentralized science, or DeSci, has been around for some time in crypto, generally in the form of DAOs crowdfunding scientific experiments that otherwise wouldn’t get funded. Pump.science emerged in the past few months, borrowing its name and funding mechanism from the popular memecoin launchpad pump.fun. 

Researchers submit experiments focused on longevity, or the increasing of lifespans, to pump.science, and a corresponding token is listed on pump.fun. As the memecoin’s market cap increases, pump.science will run experiments testing the compound on increasingly-larger animals, ending with humans. The experiments are livestreamed, so investors can see whether the compound appears to be working. The project’s docs say chemical suppliers could eventually purchase the rights to the chemical interventions from the token holders. One such licensing deal was approved on the Solana DAO platform Realms, though how this would be enforced legally is a bit of a question mark.

This is a wonky way to fund science by any standard, and pump.science has drawn its fair share of critics.

Gauntlet CEO and Robot Ventures partner Tarun Chitra, one of speculative DeSci’s loudest critics, called projects like pump.science “at best naive and at worst a predatory scam.”

With the Hedgehog Markets partnership, the rules of the pump.science game at least make a bit more sense. Mice will be injected with longevity compounds and then tested versus a control group on a rotarod, which is a rotating cylinder that can test mice motor skills. Users — brandishing data including how the compound performed in flies and what the mice’s names are, among other things — bet on which mice will perform best prior to the trials, which are then livestreamed. For Chitra at least, this could be a better road for DeSci.

Chitra said in a direct message that the lower potential returns offered by prediction markets compared to memecoins could limit the pool of bettors on DeSci prediction markets. “But philosophically, there’s nothing that is scam-like about this — it just might be very hard to bootstrap, especially if you look at how long it took Polymarket.”

Updated Jan. 10, 2025 at 3:55 pm ET: Added mention of pump.science’s first licensing deal.


Get the news in your inbox. Explore Blockworks newsletters:

Tags

Decoding crypto and the markets. Daily, with Byron Gilliam.

Upcoming Events

Hilton Park Lane

Tues - Wed, November 10 - 11, 2026

DAS London is a two-day summit at the Hilton Park Lane in London featuring conversations between the builders, allocators, and policy makers who are shaping the trajectory of the digital asset ecosystem in the UK, Europe, and North America.

Marina Bay Sands Singapore

Wednesday, October 07, 2026

DAS Asia is a a single-day summit at Marina Bay Sands Singapore featuring conversations between the builders, investors, and global leaders are shaping the trajectory of the digital asset ecosystem in Asia & North America.

recent research

Hyperliquid Purple (4).jpg

Research

HIP-3 has successfully scaled market creation on Hyperliquid, but it has not yet created a sustainable competitive deployer layer. Growth mode, USDH depreciation, high auction costs, and the 500K HYPE stake have made the model increasingly difficult for non-TradeXYZ deployers, leaving market creation concentrated around one clear outlier. We look at why deployer participation has slowed, what that means for HIP-3’s long-term design, and how tiered exchanges or temporary auction-fee relief could make smaller and more niche markets economically viable.

Newsletter

The Breakdown

Decoding crypto and the markets. Daily, with Byron Gilliam.

Blockworks Research

Unlock crypto's most powerful research platform.

Our research packs a punch and gives you actionable takeaways for each topic.

SubscribeGet in touch

Blockworks Inc.

133 W 19th St., New York, NY 10011

Blockworks Network

NewsPodcastsNewslettersEventsRoundtablesAnalytics