Get a demoExplore data

Bucking Crypto Quant Mania, Equity Vets Bet Investors Are Hungry for Fundamentals

Blockworks Exclusive: The startup, Factor6 Capital, plans to start trading outside capital early next month

article-image

Blockworks exclusive art by axel rangel

share
  • The crypto hedge fund launch is aiming to stand out in a market dominated by quants
  • Its founders have been personally investing in crypto since 2017

A couple of former biotechnology stock traders are vying to bring their investment prowess in the high-risk, high-reward sector to the crypto game.

Ralph Achacoso and Jason Zhang, both alums of healthcare-focused hedge fund firm Ghost Tree Capital, plan to launch their Factor6 Capital at the beginning of next month, according to two sources familiar with the matter.

Achacoso and Zhang are betting institutional investors will see the appeal of a discretionary, fundamental approach to deriving alpha from digital assets, bucking a trend toward systematic, black-box digital asset strategies. 

Sources said the firm believes few other market players are employing a discretionary approach — which big-time limited partners are accustomed to vetting when it comes to stock-picking portfolio managers. 

The firm started trading internal capital Tuesday in a bid to test its infrastructure before taking on outside investors. 

Achacoso declined to comment. Sources were granted anonymity to discuss sensitive business dealings. 

Factor6 has a broad investment mandate that includes layer-1 and layer-2 protocols, plus metaverse and play-to-earn gaming plays, as well as stocks with blockchain exposures and crypto derivatives. A portion of the book is earmarked for non-fungible tokens (NFTs), too. 

And the firm plans to take opportunistic private stakes, either in the form of equity or tokens, in promising digital asset startups — joining a growing number of liquid traders drawn to booming valuations in venture capital plays.

Achacoso and Zhang — who have personally been investing in crypto since 2017 — intend to make money from both long and short wagers. The idea is to profit from the upside in crypto while controlling for downside volatility. 

It’s not clear how much capital Factor6 plans to raise overall. Indications are the startup hasn’t yet begun a broad fundraising push.

Achacoso, who holds the title of chief investment officer for Factor6, worked at Ghost Tree from 2018 to 2022. Before that, he spent time at firms including PineView Asset Management, UBS and Diamondback Capital.

Zhang, the startup’s co-portfolio manager, spent about five years at Ghost Tree, preceded by stops at Visium Asset Management and Merrill Lynch.


Get the news in your inbox. Explore Blockworks newsletters:

Tags

Decoding crypto and the markets. Daily, with Byron Gilliam.

Upcoming Events

Marina Bay Sands Singapore

October 7, 2026

DAS Asia is a a single-day summit at Marina Bay Sands Singapore featuring conversations between the builders, investors, and global leaders are shaping the trajectory of the digital asset ecosystem in Asia & North America.

Hilton Park Lane, London

November 10-11, 2026

DAS London is a two-day summit at the Hilton Park Lane in London featuring conversations between the builders, allocators, and policy makers who are shaping the trajectory of the digital asset ecosystem in the UK, Europe, and North America.

Javits North

March 30-April 1, 2027

DAS NYC is a three-day summit at Javits North bringing together the builders, allocators, and policymakers shaping the future of digital assets across institutional finance and global markets.

recent research

Sponsored Article Template - DoubleZero White.png

Research

Every distributed system inherits the physical limitations, or advantages, of the network it runs on. Physics-bound systems can optimize their execution layers, compress their state, and parallelize their runtime, and still lose time they cannot recover to the speed of light through fiber and the routing decisions of carriers that are not optimized for consensus. The public internet routes traffic by least cost, not best performance. For a system where the order and timing of messages determine who earns and who loses, that is a structural tax and a measurable networking design flaw for traders.

The daily brief, in your inbox

Markets, protocols, and policy, read by 200K+ professionals.

Blockworks Inc.133 W 19th St., New York, NY 10011

Solutions

InvestorsExchangesEnterprisesOnchain Businesses

© 2026 Blockworks Inc.

TermsPrivacy PolicyPrivacy CenterNews Archive